Principal correspondents in the lettes of John Fries Frazer include Alexander Dallas Bache, Louis Agassiz, Joseph Henry, and Titian Ramsay Peale who discuss mainly general scientific topics, although personal and family matters are discussed with Bache. Topics include the University of Pennsylvania, boiler explosions, chemistry, education, the National Academy of Sciences, the Smithsonian Institution, fossils, magnetism, solar eclipses, the American Philosophical Society, weights and measures, the U.S. Coast and Geodetic Survey, scientific instruments, the American Civil War, electricity, the United States Mint, the Franklin Institute, scientists of the period, natural history, and publications.

Robert Maskell Patterson (1787-1854, APS 1809) was a professor of chemistry and natural philosophy at the University of Pennsylvania (1812-1828) and professor of natural philosophy at the University of Virginia (1828-1835). He was director of the U.S. Mint from 1835 to 1851. His father, Robert Patterson, was a revolutionary soldier, professor of mathematics at the University of Pennsylvania (1779-1814), and director of the U.S. Mint (1805-1824).

Letters (including some transcripts and photostats) from and to Vaughan from many American and British correspondents, including: Also personal correspondence and business papers of Benjamin, Charles, Petty, Samuel Sr., Samuel Jr., William, William Oliver, and Sarah Vaughan (2 boxes); lectures, mostly in shorthand (3 vols.); a large number of notes and memoranda on a wide variety of topics, such as agriculture, architecture, astronomy, diplomacy, diseases, dueling, electricity, hieroglyphs, internal improvements, medicine, meteorology, land, manufactures, politics, punctuation, religion, silk-manufacturing, stock-breeding, taxation, Unitarianism, Benjamin Franklin, John Locke, Napoleon I, Joseph Priestley, Bowdoin College, town of Hallowell, Maine; notes on the peace negotiations, 1782-1783; miscellaneous legal papers; genealogy of the Abbott-Vaughan families. For a personal account of the collection, see Mrs. Mary Vaughan Marvin, "The Benjamin Vaughan Papers," APS Proceedings 95 (1951): 246-249.